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Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as... This medicine contains Omeprazole which belongs to a group of medicines called proton pump inhibitors, which act to reduce the amount of acid in your stomach.. • If you are 45 years old or over and taking any non-prescription (over the counter) medicines for indigestion or heartburn on a regular basis Other important information Omeprazole is also available as an oral suspension and comes as an over-the-counter (OTC) medication. Buy OTC omeprazole here. Prescription omeprazole oral capsule is a delayed-release... Omeprazole (Prilosec) is available both over the counter (OTC) and by prescription. The OTC strength is 20 mg, and the prescription strengths are 10 mg, 20 mg, and 40 mg. The dosing for adults is listed below. 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