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Metoclopramide also comes in an oral solution as well as injectable forms... Generic name: metoclopramide [ MET-oh-KLOE-pra-mide ] Drug classes: GI stimulants, Miscellaneous antiemetics Medically reviewed by Sophia Entringer, PharmD. Last updated on Jan 23, 2023. Uses Warnings Before taking Dosage Side effects Interactions What is Reglan? Reglan increases muscle contractions in the upper digestive tract. It is particularly effective at treating nausea caused by motion sickness and inner ear problems. Metoclopramide - this medicine acts in the gut. Metoclopramide works to speed up the transit of food through the gut. This treatment for nausea is often used when the symptoms are caused by gut problems or a migraine. Metoclopramide works by blocking a natural substance (dopamine) which can cause nausea and vomiting. 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